Jon Hendry Pickup, who joined the group less than two years ago, will hand the role to Karen Jones, the former chief executive of Spirit Group.
Jones, 61, will assume the role of executive chairwoman.
Prezzo was founded and floated by the Kaye family and taken private by TPG in January 2015 in a deal valuing the business at £304 million. After the buyout, the group expanded from about 250 restaurants to 300, revamped its Prezzo brand and launched a third brand, Mexico.
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